MAN gets bad reports, but in my experience if specified correctly for the job and with drivers who actually give a bugger are far better than one might think from what some drivers say, i’d gladly have another but specified better for the job in hand.
440 isn’t up to max weight work IMHO, and it will give cooling problems if not looked after really well, i could write a book on waterwork probs but our vehicles were wrongly specced when new the 440 engine simply isn’t up to running 44 ton day and night, but then underspecifying (or rather one spec fits all) lorries seems to be a national disease so one can hardly blame any maker for supplying a too small engine if thats what the customer requires, you wouldn’t specify a 1.6 PSA Diesel to power a Range Rover towing a bloody great boat so why expect an underpowered undersized lorry engine to cope when its having to work too hard constantly, but as mere drivers we don’t know anything 
Having said that, mine has done well over 1/2 million K’s now and the engine is sweet and quiet, from cold too, which is more than can be said for some of the so called premium makes we have which sound like a bag of spanners and drink oil like its about to be banned and have seen several new gearboxes between them.
Despite predictions here of doom no turbo failures, though i do allow it warm up and cool down, the cab is a bit brittle except for the indicator self cancel pawl which is made out of kryptonite or summat, cos i;d like it to break but the bloody thing is tough as hell.
It doesn’t blow bulbs, which are easy to change anyway.
The exhaust brake needs annual adjusting up but works well, in all that mileage i’ve just had the third set of drive axle pads fitted and 1/2 through the second set on steer axle, original mid lift pads, no new discs fitted, a good O/D could get the full 1/2mill from one set but ours get used by every tom ■■■■ and igor when we’re not on shift and you can tell from the thick black carbon round the wheels when you come back after 2 days off that its been driven on the brakes by idiots.
No suspension or other problems, couple of chafed wires which needed sorting, simple fixes, all in all mine has been a decent lorry and i would have no complaints if i’d leased it meself, the main dealer workshops have looked after mine well always fixing things without me having to ask but i present it in the sort of condition a mechanic would want to work on.
The 480 engine in comparison from all i hear is pretty well trouble free, so if you want an MAN try to find one of those instead.
Arsetronic gearbox is one of the most horrible to drive made, but it is superbly reliable and durable, it just keeps going, something other makers who get raved about on here as the holy grail can’t lay claim to, in MAN’s the release bearings are inclined to drop apart at 1/2 a million kms, so if my experience is anything to go by, if you detect clutch judder when reversing and the mileage is getting to 1/2 mill, consider shoving it in for a new clutch and thrust bearing cos when it goes there is no prior warning and its a tow in job.