atm thinking of heading straight down towards reims, dijon then pick up for geneva, through mont blanc, pick up for milan, bologna, san marino then ancona?
Personally id take the frejus then obviously torino straight out to piacenza and on from there i think its about 50km longer but roads seem to be quicker coming up to and down from the frejus. Ive known people to use the frejus for milan and the blanc for genoa and south so i think theyre either getting their tunnels mixed up or it must be pretty close
If you get the chance,try Brescia Est truck stop,secure site,good places to eat,a hotel with discounts for drivers,and if weekended,you can hire a car and see the Italian lakes and be a tourist,they have a gym in the truck stop too,if you fancy a full cardio vascular work out to burn off all that pizza and Lavaza coffee.
It may prevent a myacardial infarction.
Why would you be going anywhere near Brescia if you’re going to Ancona 
Three ways to go really, Blanc, Frejus or Swiss, the first two I would go Allessandria, Piacenza, the latter straight to Milan and south to Piacenza, from there Modena, then chuck a left, through Imola and then down the coast to Ancona
You’ve got Campogalliano (if it still exists) for a night out or Modena Nord depending on what kind of entertainment you’re looking for 
Hi Mark
You forgot about the train from Freiburg to Novara !You get your rest whilst still on the move.
HUPAC Contact Info:
FREIBURG BREISGAU
DE SVG Südbaden
Terminal Freiburg
Emmy Nother Strasse
D-79108 Freiburg
Opening time
MO 04:00-24:00 TU-FR 00:00-24:00
SA 00:00-12:00 SU 11:00-22:40
Tel 0049 761 500031
Fax 0049 761 506531
terminal.freiburg@ralpin.com
GS OVERLAND:
Hi Mark
You forgot about the train from Freiburg to Novara !You get your rest whilst still on the move.
HUPAC Contact Info:
FREIBURG BREISGAU
DE SVG Südbaden
Terminal Freiburg
Emmy Nother Strasse
D-79108 FreiburgOpening time
MO 04:00-24:00 TU-FR 00:00-24:00
SA 00:00-12:00 SU 11:00-22:40Tel 0049 761 500031
Fax 0049 761 506531
terminal.freiburg@ralpin.com
I would like to point out that, IN THEORY and on paper, you get your rest.
In actual fact, you’ll be knackered by the time you reach Ancona because you only get very poor rest while on that train. I wouldn’t expect to put a full driving day in after it.
The train has several changes of engine, one of which is to put the engine at the other end (it’s roll on - roll off). It gets put into sidings to let faster trains pass several times, all of which involve a good bit of jolting, banging and clattering. You will be sleeping in a small compartment with two or three other drivers. There are no rules about drivers being the same nationality or even speaking the same language.
The trip in day-time has fantastic scenery, or so I’m told. I’ve only done it at night, so all I saw was a few spots of light at all sorts of strange angles and heights. A bit like driving through Austria in the dark 
Germany/Austria and use the train from Worgl in Austria to the Brenner it’s the same price to drive as tolls but you save fuel and get your rest if you work it right or Belgium/Lux/France down to Pontarlier and over the Simplon you will need T-forms.
Rgs
JJSL